5-HT4 partial agonist
5-HT4 serotonin receptor partial agonist
- Partial activation of enteric 5-HT4 → acetylcholine release and prokinesis
- Relieves constipation-predominant irritable bowel syndrome
- Partial agonism limits maximal motility stimulation
- Partial prokinetic activity at 5-HT4
Drugs with this mechanism (1)
- Tegaserod — 5-HT4 agonist for IBS-C; withdrawn then reintroduced with restrictions.
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