5-HT1A antagonist
5-HT1A serotonin receptor antagonist
- Autoreceptor disinhibition → ↑ serotonin firing/release
- Proposed to accelerate antidepressant onset by preventing autoreceptor braking
- ↑ serotonin release downstream
- May interfere with sleep architecture
Drugs with this mechanism (1)
- Pindolol — Nonselective beta blocker whose intrinsic sympathomimetic activity preserves resting heart rate; hypertension.
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