Methylphenidate CD
METADATE CD
Pronunciation: meth-il-FEN-i-dayt
“Write a line on Math final date”
Wide eyes → symbol for stimulant
What it isMethylphenidate CD (METADATE CD, 2001) inhibits dopamine and norepinephrine reuptake for ADHD; approved ages: 6-17, adults.
Why this oneIts 30% IR / 70% DR beads mimic BID coverage for 8-12 h (Carlat Table 1), with a smaller early pulse than Ritalin LA; capsule contents are sprinklable.
What limits itAppetite loss and insomnia are common; monitor growth, pulse and blood pressure, and protect against misuse.
FDA-approved for
- ADHD (2001)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| ADHD | Peds 6–15 y | 20 mg QD | individualized | 60 mg/day |
Titration May increase after weekly intervals
Renal Undefined (not studied; minimal effect expected)
Hepatic Undefined (not studied; minimal effect expected)
Instructions
- Take orally once daily in the morning before breakfast
- Swallow whole with liquid, or open capsule and sprinkle onto small amount of applesauce and take immediately
- Do not crush or chew capsule or contents
- Allow at least 14 days after stopping an MAOI before starting
Available strengths
- ER cap 10, 20, 30, 40, 50, 60 mg
- cap 20, 40, 60, 80, 100 mg
- tab 5, 10, 20 mg
- ER tab 10, 18, 20, 27, 36, 45, 54, 63, 72 mg
- ODT 8.6, 17.3, 25.9 mg
- chew tab 2.5, 5, 10, 20, 30, 40 mg
- ER susp 600 mg/120 mL
- ER susp 750 mg/150 mL
- + 5 other marketed forms not shown
Contraindications
- Concomitant treatment with monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of an MAOI, because of the risk of hypertensive crisis
- Hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency (contains sucrose)
- Pheochromocytoma or a history of pheochromocytoma
Cautions
- Risks to patients with serious cardiac disease — avoid in structural cardiac abnormalities
- Increased blood pressure and heart rate — monitor
- Psychiatric adverse reactions (new psychotic/manic symptoms)
- Priapism
- Peripheral vasculopathy, including Raynaud's phenomenon
- Long-term growth suppression in pediatric patients — monitor height/weight
- Acute angle closure glaucoma; increased intraocular pressure
- Motor and verbal tics, worsening of Tourette's syndrome
Adverse reactions
- Anorexia
- Insomnia
- Headache
- Abdominal pain
Pregnancy Inconsistent findings on birth defects/miscarriage; CNS stimulants may cause vasoconstriction/decreased placental perfusion; pregnancy registry available
Lactation Methylphenidate present in human milk (infant dose 0.16–0.7% maternal); monitor infant for agitation, insomnia, anorexia, reduced weight gain
Cost
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 10 mg | ER cap | per unit | $2.40/ea | not offered |
| 20 mg | ER cap | per unit | $1.54/ea | not offered |
| 30 mg | ER cap | per unit | $1.90/ea | not offered |
| 40 mg | ER cap | per unit | $1.65/ea | not offered |
| 50 mg | ER cap | per unit | $1.57/ea | not offered |
| 60 mg | ER cap | per unit | $5.84/ea | not offered |
Other forms: Methylphenidate (RITALIN) · Methylphenidate ER chewable (QUILLICHEW ER) · Methylphenidate ER suspension (QUILLIVANT XR) · Methylphenidate ER (Relexxii) · Methylphenidate LA (RITALIN LA) · Methylphenidate ER (OROS) (CONCERTA) · Methylphenidate XR-ODT (COTEMPLA XR-ODT) · Methylphenidate patch (DAYTRANA) · Methylphenidate ER evening-dosed (JORNAY PM) · Methylphenidate oral solution (METHYLIN SOLUTION)
⚠ BOXED WARNING
- Abuse, misuse and addiction
Classes and tags
Clinical profile
Legacy pregnancy categoryC
Defining liabilityHypertension, appetite/weight effects, misuse and stimulant-induced psychosis or arrhythmia.
Open Methylphenidate CD in the interactive console ↗
Memory aids: interaction avatars
