Tryptophan
precursor
“L tripped a fan”
What it isEssential amino acid and the precursor of serotonin and melatonin.
Why this oneIt is the rate-limiting substrate for serotonin synthesis, which is why depletion studies lower mood.
What limits it⚑ Contaminated product caused the 1989 eosinophilia-myalgia epidemic. Serotonin syndrome with serotonergic drugs.
FDA-approved for
- dietary supplement / serotonin precursor
Off-label
- insomnia
- antidepressant augmentation
Available strengths
- cap 500, 1000 mg
NO BOXED WARNINGS
Principal risk⚑ Contaminated product caused the 1989 eosinophilia-myalgia epidemic
Classes and tags
Clinical profile
Defining liabilitySerotonergic interactions, drowsiness and hypersensitivity