Travoprost

TRAVATAN Z

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Pronunciation: TRA-voe-prost

Travoprost ballicule: receptor binding, kinetics and half-life diagram — Mechanism of action: Travoprost ballicule

What it isProstaglandin FP-receptor agonist increasing uveoscleral outflow; open-angle glaucoma and ocular hypertension.

Why this oneThe branded formulation avoids benzalkonium chloride, which can help when ocular-surface irritation limits other drops.

What limits itIris darkening may be permanent; eyelash growth, periocular change, and conjunctival hyperemia are common local effects.

Travoprost molecular structure (skeletal formula) — Molecular structure: Travoprost

FDA-approved for

open-angle glaucoma / ocular hypertension (2001)

FDA label

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FDA dosing	Population	Start	Target	Max
Elevated IOP in open-angle glaucoma or ocular hypertension	Adults	1 drop in affected eye(s) QHS (evening)	1 drop QD (evening)	1 drop QD

Renal Studied in renal impairment; no clinically relevant changes observed

Hepatic Studied in hepatic impairment; no clinically relevant changes observed

More frequent than once-daily administration may decrease the IOP-lowering effect

Instructions

Instill once daily in the evening; do not exceed once-daily dosing
If using other topical ophthalmics, administer at least 5 minutes apart
Remove contact lenses before instillation; reinsert 15 minutes after

Available strengths

drops 0.004 %
sol 0.04 mg/mL
implant 75 mcg

Cautions

Permanent increased iris pigmentation; periorbital and eyelash pigmentation changes
Gradual eyelash changes (length, thickness, number)
May exacerbate active intraocular inflammation (e.g., uveitis)
Macular edema, including cystoid; caution in aphakic/pseudophakic patients with torn posterior capsule
Not evaluated for angle-closure, inflammatory, or neovascular glaucoma
Bacterial keratitis with contaminated multidose containers

Adverse reactions

Conjunctival/ocular hyperemia (30–50%)
Decreased visual acuity
Eye discomfort
Foreign body sensation
Eye pain
Pruritus

Pregnancy No adequate human studies; animal embryo-fetal lethality, abortion, and premature delivery at clinically relevant doses; use only if benefit justifies risk

Lactation Unknown if present in human milk; excreted in rat milk

Cost

Travoprost (TRAVATAN Z)

Strength		#/mo	generic $/unit	CostPlus
0.004 %	drops	per unit		not offered

NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Travoprost is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.

Generic entry2013

NO BOXED WARNINGS

Principal riskPermanent iris darkening

Classes and tags

Clinical profile

Therapeutic safety burden0 / 4

Overdose danger0 / 4

Weight-gain liability0 / 4

Sedation liability0 / 4

QT / Torsades0 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk0 / 4

Legacy pregnancy categoryUnknown / historical label unavailable

Defining liabilityLocal irritation, sensitization or administration-site injury; negligible systemic toxicity at usual use.

Open Travoprost in the interactive console ↗