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Trandolapril

MAVIK

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Pronunciation: tran-DOEL-a-pril

Trandolapril ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Trandolapril ballicule
Trandolapril MAVIK mascot mnemonic cartoon
Visual mnemonic: Trandolapril mascot
“May Vick trans(fer) dolla Prils?”
Easter/April theme → ACE inhibitor = -pril (aPril)
Bananas in bunches → ↑ serum potassium

What it isACE inhibitor; hypertension and post-infarction left ventricular dysfunction.

Why this oneA very long half-life gives true once-daily cover.

What limits itCough, hyperkalemia and the hemodynamic creatinine rise. Contraindicated in pregnancy.

Trandolapril molecular structure (skeletal formula)
Molecular structure: Trandolapril

FDA-approved for

⚠ BOXED WARNING

Generic entry2006

Classes and tags

Clinical profile

Therapeutic safety burden2 / 4
Overdose danger2 / 4
Weight-gain liability0 / 4
Sedation liability0 / 4
QT / Torsades0 / 4
Direct muscarinic antagonism0 / 4
Embryofetal risk4 / 4

Legacy pregnancy categoryD

Defining liabilityHyperkalemia, kidney injury, angioedema, fetal toxicity and increased lithium exposure.

Active metabolites

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Memory aids: interaction avatars

Trandolapril Box: minimal PK interactions avatar mnemonic
Box: minimal PK interactions

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