Thiamine
VITAMIN B1
Pronunciation: THYE-a-min
“You be one Thigh man!”
alcoholism frequently leads to Vitamin B1 deficiency
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What it isVitamin B1 cofactor for carbohydrate metabolism; thiamine deficiency and Wernicke encephalopathy.
Why this oneSuspected Wernicke encephalopathy is treated immediately without waiting for tests; glucose should not be delayed.
What limits itSevere deficiency needs parenteral replacement because oral absorption is unreliable; rare anaphylaxis warrants monitoring.
FDA-approved for
- thiamine deficiency
- Wernicke encephalopathy
Available strengths
- tab 50, 100 mg (also 250, 500)
- inj 100 mg/mL
NO BOXED WARNINGS
Principal riskrare anaphylaxis with parenteral administration
Generic entry1982
Classes and tags
Clinical profile
Legacy pregnancy categoryA
Defining liabilityUsually well tolerated at replacement doses; excessive dosing can cause agent-specific metabolic or organ toxicity.