THDOC
allotetrahydro-DOC
What it isTetrahydrodeoxycorticosterone, an endogenous neurosteroid and GABA-A positive modulator.
Why this oneIt rises with stress and may be a homeostatic brake on the stress response.
What limits itIt acts at extrasynaptic receptors that benzodiazepines cannot reach, like allopregnanolone.
NO BOXED WARNINGS
Principal riskIt acts at extrasynaptic receptors that benzodiazepines cannot reach, like allopregnanolone