Temsavir
from fostemsavir
Pronunciation: TEM-sa-veer
What it isThe active moiety of fostemsavir — an HIV-1 attachment inhibitor that binds gp120 and blocks CD4 engagement.
Why it mattersIt attacks the virus before entry, at a step no other approved class touches, preserving activity in multidrug-resistant infection.
What it changesIt is reserved for heavily treatment-experienced patients, and gp120 polymorphisms can confer primary resistance.
NO BOXED WARNINGS