Temazepam
RESTORIL
Pronunciation: te-MAZ-e-pam
“The ‘mazing Rest troll”
What it isIntermediate-duration GABA-A positive allosteric modulator; insomnia.
Why it mattersGlucuronidation rather than oxidative metabolism makes it a cleaner hypnotic choice in liver disease.
What it changesDependence, withdrawal, and falls limit use; combining it with opioids can cause fatal respiratory depression.
FDA-approved for
- insomnia (1981)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Insomnia (short-term) | Adults | 15 mg QHS | 15 mg QHS (range 7.5–30 mg) | 30 mg QHS |
| Insomnia | Elderly/debilitated | 7.5 mg QHS | 7.5 mg QHS until response determined |
Renal Undefined
Hepatic Undefined
Instructions
- Take orally before retiring
- 7.5 mg may suffice for transient insomnia
Available strengths
- cap 7.5, 15, 22.5, 30 mg
Contraindications
- Pregnancy (Category X) — may cause fetal harm
Cautions
- CNS depression / next-day impairment
- Abuse, dependence, and withdrawal potential (benzodiazepine)
- Neonatal CNS depression with use in late pregnancy
Adverse reactions
- Drowsiness, headache, fatigue, nervousness, lethargy, dizziness, nausea, hangover
Pregnancy Contraindicated (Category X) — may cause fetal harm
Lactation Undefined
Cost
Temazepam (RESTORIL)
What pharmacies pay · NADAC 9/30/26
| Strength | #/mo | generic $/mo | CostPlus | |
|---|---|---|---|---|
| 7.5 mg | cap | 30 qd | $25.01 | not offered |
| 15 mg | cap | 30 qd | $2.30 | not offered |
| 22.5 mg | cap | 30 qd | $46.48 | not offered |
| 30 mg | cap | 30 qd | $2.68 | not offered |
Generic entry1985
⚠ BOXED WARNINGS
- Risk from concomitant use with opioids
- Abuse, misuse and addiction
- Dependence and withdrawal reactions
Classes and tags
Clinical profile
Legacy pregnancy categoryX
Defining liabilitySedation, falls, dependence and additive respiratory depression with opioids or other CNS depressants.
Active metabolites
Open Temazepam in the interactive console ↗
Memory aids: interaction avatars
