Sulpiride
DOLMATIL
What it isSelective D2 and D3 antagonist; schizophrenia and, at low dose, depression outside the US.
Why this oneLow doses preferentially block presynaptic autoreceptors, which is the basis for the antidepressant use.
What limits itMarked hyperprolactinemia. Renally cleared; not US-approved.
FDA-approved for
- schizophrenia (non-US)
Off-label
- schizophrenia
- depression at low dose (approved in Europe and Japan)
⚠ BOXED WARNING
- Increased mortality in elderly patients with dementia-related psychosis
Classes and tags
Clinical profile
Defining liabilityHyperprolactinemia, extrapyramidal effects and torsades risk