Substance P
endogenous
What it isEndogenous tachykinin acting at the NK1 receptor.
Why this oneIt is the ligand whose blockade by aprepitant prevents delayed chemotherapy nausea.
What limits itNK1 antagonists have repeatedly failed as analgesics despite substance P’s role in nociception.
NO BOXED WARNINGS
Principal riskNK1 antagonists have repeatedly failed as analgesics despite substance P’s role in nociception