Simethicone
GAS-X
Pronunciation: sye-METH-i-koen
What it isNonabsorbed silicone antifoaming agent that coalesces gas bubbles; symptomatic bloating and flatulence.
Why this oneBecause it stays in the gut, systemic toxicity and drug interactions are negligible.
What limits itDiscontinue if symptoms do not improve; evidence is weak, and it changes bubble dispersion rather than gas production.
FDA-approved for
- flatulence / gas
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Gas / bloating relief | Adults | 1-2 tablets PRN after meals & QHS | 4 tablets/24 h |
Renal Undefined
Hepatic Undefined
Instructions
- Chew tablets completely; do not swallow whole
- Do not exceed 4 tablets in 24 h except under physician supervision
Available strengths
- chew tab 80, 125 mg
- cap 125, 180, 250, 500 mg
- emulsion 20 mg/.3 mL
- sol 125 mg/5 mL
- susp 20 mg/.3 mL
- cream 1.5, 3 g/100 g
- cream 60 mg/g
- lotion 1 g/100 mL
- + 2 other marketed forms not shown
Pregnancy Undefined
Lactation Undefined
Cost
Simethicone (GAS-X)
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 80 mg | chew tab | per unit | not offered | |
| 125 mg | chew tab | per unit | not offered |
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Simethicone is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.
NO BOXED WARNINGS
Principal riskLittle; not absorbed
Classes and tags
Clinical profile
Defining liabilityLow toxicity; persistent GI symptoms need evaluation