Sevoflurane
ULTANE
What it isVolatile GABA-A enhancer and NMDA antagonist; induction and maintenance of anesthesia.
Why this oneLow pungency makes it the only volatile suited to inhalational induction, so it is standard in children.
What limits itMalignant hyperthermia trigger. Compound A formation with low fresh gas flow; emergence delirium in children.
FDA-approved for
- inhalational anesthesia (1995)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| General anesthesia — maintenance | Adults & peds | 0.5-3% inhaled, ± nitrous oxide | surgical MAC by age | |
| General anesthesia — induction | Adults & peds | mask induction, concentration titrated |
Renal Undefined
Hepatic Undefined
Instructions
- Deliver from a vaporizer calibrated specifically for sevoflurane
- Replace desiccated CO2 absorbent (exothermic reaction risk / Compound A)
- Individualize based on patient response
Available strengths
- sol 100 %
Contraindications
- Known or suspected genetic susceptibility to malignant hyperthermia
- Known or suspected sensitivity to sevoflurane or other halogenated inhalational anesthetics
Cautions
- Malignant hyperthermia
- Seizures (postmarketing, especially in children/young adults)
- QT prolongation / Torsade de Pointes
- Perioperative hepatic dysfunction/hepatitis
- Compound A formation with desiccated CO2 absorbents
Adverse reactions
- Nausea
- Vomiting
- Hypotension
- Agitation
- Somnolence
- Increased cough
- Bradycardia
- Laryngospasm
- Shivering
Pregnancy No adequate human data; animal reduced fetal weight; NMDA/GABA anesthetics may increase neuronal apoptosis with >3 h exposure
Lactation Undefined
Cost
Sevoflurane (ULTANE)
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 100 % | sol | per unit | not offered |
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Sevoflurane is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.
NO BOXED WARNINGS
Principal riskMalignant hyperthermia trigger; emergence delirium in children
Classes and tags
Clinical profile
Defining liabilityCardiorespiratory depression and malignant hyperthermia