Not available in the U.S.
Rilmenidine
HYPERIUM
What it isOxazoline I1 imidazoline agonist used for hypertension in Europe; not marketed in the United States.
Why this oneLike moxonidine it favors the I1 site over alpha-2, so it sedates less than clonidine while still reducing sympathetic outflow.
What limits itRenally cleared, so dosing falls with impaired renal function. Rebound on abrupt withdrawal is milder than clonidine but is still described.
Off-label
- hypertension (approved outside the US)
NO BOXED WARNINGS
Classes and tags
Clinical profile
Defining liabilityBradycardia, orthostatic hypotension and somnolence