Riboflavin
VITAMIN B2
What it isVitamin B2, precursor of FAD and FMN; deficiency and migraine prophylaxis.
Why this oneHigh-dose riboflavin has modest evidence for migraine prevention and is almost free of toxicity.
What limits itIt turns urine bright yellow, which alarms patients if unwarned. Migraine benefit takes about three months.
FDA-approved for
- riboflavin deficiency
- migraine prophylaxis (off-label)
Off-label
- riboflavin deficiency
- migraine prophylaxis
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Not stated on label (oral vitamin B2 supplement tablet) | Adults ≥18 yr | 100 mg QD | 100 mg QD | 100 mg QD |
Renal Undefined
Hepatic Undefined
Instructions
- Take preferably with a meal, or as directed by a physician.
- Under 18 yr: consult a physician before use.
Available strengths
- drops 0.146/0.146, 0.239/0.177 %/mL
Pregnancy Undefined
Lactation Undefined
Cost
Riboflavin (VITAMIN B2)
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 0.146/0.146 %/mL | drops | per unit | not offered | |
| 0.239/0.177 %/mL | drops | per unit | not offered |
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Riboflavin is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.
NO BOXED WARNINGS
Principal riskIt turns urine bright yellow, which alarms patients if unwarned
Classes and tags
Clinical profile
Legacy pregnancy categoryNot assigned — OTC/monograph
Defining liabilityUsually well tolerated at replacement doses; excessive dosing can cause agent-specific metabolic or organ toxicity.