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Psyllium

METAMUCIL

Pronunciation: SIL-i-yum

Psyllium ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Psyllium ballicule
Psyllium METAMUCIL mascot mnemonic cartoon
Visual mnemonic: Psyllium mascot
“Metamu–Silly Yum!”

What it isBulk-forming soluble fiber that makes a viscous gel; constipation and modest LDL lowering.

Why this oneIt can normalize both hard and loose stools while also lowering LDL slightly.

What limits it⚑ Take with ample fluid or risk esophageal or bowel obstruction; bloating and drug-binding require separation.

FDA label

FDA dosingPopulationStartTargetMax
Occasional constipation / irregularity (bulk-forming fiber laxative)Adults & children >=12 yr5 capsules with >=8 oz liquid at first sign of irregularity5 capsules up to TID5 capsules TID
Occasional constipation / irregularityChildren <12 yrAsk a doctor——

Renal Undefined

Hepatic Undefined

Instructions

Available strengths

Cautions

Adverse reactions

Pregnancy Undefined

Lactation Undefined

Cost

Psyllium (METAMUCIL)
Strength#/mogeneric $/moCostPlus
520 mgcap90 TIDnot offered
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Psyllium is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.

NO BOXED WARNINGS

Principal riskObstruction without adequate fluid

Classes and tags

Clinical profile

Therapeutic safety burden0 / 4
Overdose danger2 / 4
Weight-gain liability0 / 4
Sedation liability0 / 4
QT / Torsades0 / 4
Direct muscarinic antagonism0 / 4

Defining liabilityChoking or obstruction if swallowed without sufficient liquid

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