Pregnanolone
eltanolone
What it isEndogenous neurosteroid and GABA-A positive modulator.
Why this oneIt is one of the neurosteroids whose fluctuation links hormonal state to GABAergic tone and mood.
What limits itPoor oral bioavailability, which is why synthetic analogues were developed instead.
NO BOXED WARNINGS
Principal riskPoor oral bioavailability, which is why synthetic analogues were developed instead
Classes and tags
Clinical profile
Defining liabilityAnesthesia with respiratory and hemodynamic depression