PERCOCET
Combination product
Pronunciation: ox-i-KOE-doen and a-set-a-MEE-noe-fen (PER-koe-set)
Combination of Oxycodone and Acetaminophen.
Each component keeps its own pharmacology page; the combination itself adds no new mechanism.
Components (2)
FDA label
Read the full label on DailyMed ↗
BOXED WARNING Addiction, abuse, and misuse (can lead to overdose and death); life-threatening respiratory depression; accidental ingestion (fatal in children); neonatal opioid withdrawal syndrome (NOWS); risk from concomitant use with benzodiazepines or other CNS depressants; CYP3A4 interactions; hepatotoxicity (acetaminophen); Opioid Analgesic REMS.
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate | Adults | 2.5 mg/325 mg: 1–2 tablets q6h PRN (lowest effective dose) | Acetaminophen ≤4 g/day |
Renal Undefined
Hepatic Undefined
q6h PRN dosing
Instructions
- Use the lowest effective dosage for the shortest duration
- Do not stop abruptly in physically dependent patients; taper gradually (e.g., 10–25% of total daily dose every 2–4 weeks)
- Total acetaminophen from all sources should not exceed 4 g/day
Available strengths
- tab 2.5/325, 5/325, 7.5/325, 10/325 mg
Contraindications
- Significant respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment
- Known or suspected gastrointestinal obstruction, including paralytic ileus
Cautions
- Respiratory depression
- Addiction, abuse, and misuse
- Serotonin syndrome with serotonergic drugs
- Adrenal insufficiency
- Severe hypotension
- Hepatotoxicity (acetaminophen, esp. >4 g/day)
- Risk with CYP3A4 inhibitors/inducers
Adverse reactions
- Lightheadedness, dizziness, drowsiness/sedation
- Nausea, vomiting, constipation
- Respiratory depression (serious)
- Euphoria, dysphoria, pruritus
Pregnancy Undefined
Lactation Undefined
Cost
PERCOCET
What pharmacies pay · NADAC 9/30/26
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 2.5/325 mg | tab | per unit | $0.76/ea | not offered |
| 5/325 mg | tab | per unit | $0.12/ea | not offered |
| 7.5/325 mg | tab | per unit | $0.18/ea | not offered |
| 10/325 mg | tab | per unit | $0.23/ea | not offered |
Part D rank #64.