Norclobazam
N-desmethylclobazam
What it isN-desmethylclobazam, the major active metabolite of clobazam.
Why it mattersIt carries most of clobazam’s anticonvulsant effect and has a much longer half-life than the parent.
What it changesCYP2C19 poor metabolizers accumulate it severalfold, and cannabidiol raises it sharply — a common cause of sedation in Dravet syndrome.
FDA-approved for
- Lennox-Gastaut syndrome (active metabolite of clobazam)
NO BOXED WARNINGS
Principal riskCYP2C19 poor metabolizers accumulate it severalfold, and cannabidiol raises it — a common cause