Not available in the U.S.
Moxonidine
PHYSIOTENS
What it isCentrally acting antihypertensive that works mainly at the I1 imidazoline receptor rather than at alpha-2, and is not marketed in the United States.
Why this oneThe I1 selectivity is the point: it lowers sympathetic outflow with much less of the sedation and dry mouth that limit clonidine.
What limits itRenally cleared with a short half-life. The MOXCON heart-failure trial was stopped early for excess mortality, so it is not used in systolic heart failure.
Off-label
- hypertension (approved outside the US)
NO BOXED WARNINGS
Classes and tags
Clinical profile
Defining liabilityBradycardia, conduction block, hypotension and somnolence