Moexipril
UNIVASC
Pronunciation: moe-EX-i-pril
“Moe exits the Universe”
Easter/April theme → ACE inhibitor = -pril (aPril)
Bananas in bunches → ↑ serum potassium
What it isACE inhibitor suppressing angiotensin II and aldosterone; hypertension.
Why this oneIts absorption falls with food, making fasting administration a drug-specific inconvenience among ACE inhibitors.
What limits itCough, hyperkalemia, kidney injury, angioedema, and fetal toxicity remain class hazards.
FDA-approved for
- hypertension (1995)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Hypertension | Adult | 7.5 mg QD | 30 mg/day (1–2 divided doses) |
Renal CrCl ≤40 mL/min/1.73m²: start 3.75 mg QD; titrate up to max 15 mg/day.
Hepatic Undefined
Instructions
- Take one hour before meals.
- In patients on a diuretic, discontinue it 2–3 days before starting if possible; if not, start at 3.75 mg under supervision.
- Discontinue as soon as pregnancy is detected.
Available strengths
- tab 7.5, 15 mg
Contraindications
- History of angioedema related to previous ACE inhibitor treatment.
- Co-administration with aliskiren in patients with diabetes.
Cautions
- Anaphylactoid reactions and angioedema
- Symptomatic/postural hypotension
- Neutropenia/agranulocytosis
- Fetal/neonatal morbidity and mortality
- Hyperkalemia
- Cough
Adverse reactions
- Cough
- Dizziness
- Diarrhea
- Flu syndrome
- Fatigue
- Pharyngitis
- Flushing
- Rash
- Myalgia
Pregnancy Fetal toxicity — discontinue when pregnancy is detected (RAS-acting drug).
Lactation Undefined
Cost
Generic entry2003
⚠ BOXED WARNING
- Fetal toxicity
Classes and tags
Clinical profile
Legacy pregnancy categoryD
Defining liabilityHyperkalemia, kidney injury, angioedema, fetal toxicity and increased lithium exposure.
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