Moclobemide
MANERIX
“Mannerly Mock obedience”
What it isReversible inhibitor of MAO-A; depression outside the US.
Why this oneReversibility means tyramine displaces it, so the dietary restriction of irreversible MAOIs largely disappears.
What limits itSerotonin syndrome with serotonergic drugs still applies. Not US-approved.
FDA-approved for
- major depressive disorder (non-US)
Off-label
- depression
- social anxiety disorder (approved in Europe, Canada, Australia)
⚠ BOXED WARNING
- Suicidal thoughts and behaviors in patients under 25
Classes and tags
Clinical profile
Defining liabilitySerotonergic interactions and reversible monoamine-oxidase inhibition
Serotonin and MAOI
Provisional washout figures
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