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Methylcellulose

CITRUCEL

Methylcellulose ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Methylcellulose ballicule

What it isA semisynthetic, non-fermentable soluble bulk fiber for constipation.

Why this oneIts soluble, nonfermentable cellulose is gas-sparing and avoids the allergy risk of psyllium.

What limits itIt can obstruct without adequate water. Separate it from other oral drugs because absorption may be delayed.

FDA label

FDA dosingPopulationStartTargetMax
Fiber therapy / bulk laxative (OTC Uses section not in extract)adults & children >12 yr2 caplets with ≥8 oz fluid; increase as needed up to 6x/dayas needed12 caplets/day
Fiber therapy / bulk laxativechildren 6–12 yr1 caplet with ≥8 oz fluid; increase as needed up to 6x/dayas needed6 caplets/day
Fiber therapy / bulk laxativechildren <6 yrConsult a physicianConsult a physicianConsult a physician

Renal Undefined

Hepatic Undefined

Instructions

Available strengths

Cautions

Pregnancy Undefined

Lactation Undefined

Cost

Methylcellulose (CITRUCEL)
Strength#/mogeneric $/unitCostPlus
500 mgtabper unitnot offered
2 g/dosepowderper unitnot offered
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Methylcellulose is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.

NO BOXED WARNINGS

Principal riskChoking if taken without enough fluid

Classes and tags

Clinical profile

Therapeutic safety burden0 / 4
Overdose danger2 / 4
Weight-gain liability0 / 4
Sedation liability0 / 4
QT / Torsades0 / 4
Direct muscarinic antagonism0 / 4
Embryofetal risk1 / 4

Defining liabilityChoking or bowel obstruction with inadequate fluid

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