Methicillin

historical

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Methicillin ballicule: receptor binding, kinetics and half-life diagram — Mechanism of action: Methicillin ballicule

What it isPenicillinase-resistant penicillin; withdrawn.

Why this oneIt gave the name to methicillin-resistant Staphylococcus aureus, which is its only remaining significance.

What limits itInterstitial nephritis ended its use; oxacillin and nafcillin replaced it. Susceptibility is still reported as methicillin-sensitive or resistant.

Methicillin molecular structure (skeletal formula) — Molecular structure: Methicillin

FDA-approved for

staphylococcal infections (1960)

NO BOXED WARNINGS

Principal riskWithdrawn for interstitial nephritis

Classes and tags

Antibacterial drugs
Antimicrobials
Beta-lactam antibiotics
Discontinued drugs
Penicillins
Renally cleared drugs
Very short half-life drugs

Clinical profile

Therapeutic safety burden2 / 4

Direct muscarinic antagonism0 / 4

Defining liabilityInterstitial nephritis during prolonged therapy

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