Methanol
toxic alcohol
What it isToxic alcohol metabolized by alcohol dehydrogenase to formic acid.
Why this oneNot a drug — it defines the toxidrome that fomepizole and ethanol treat by competing for ADH.
What limits it⚑ The parent is relatively harmless; FORMATE causes the blindness and acidosis, so treatment must start before metabolism completes. Anion-gap acidosis with an osmolar gap.
NO BOXED WARNINGS
Principal riskFormate causes blindness and acidosis, not the parent