Mecamylamine

FDA label

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Titration Increase by 2.5 mg increments at intervals of not less than 2 days until desired response.

Renal Contraindicated in uremia; give with great discretion, if at all, when renal insufficiency is manifested by rising/elevated BUN.

Hepatic Undefined

Instructions

• Give after meals for more gradual absorption; keep timing relative to meals consistent.
• Give the larger dose at noon (and perhaps evening); morning dose small or omitted.
• Reduce dose of concomitant antihypertensives to avoid excessive hypotension (continue thiazides at usual dose).

Available strengths

• tab 2.5 mg

Contraindications

• Mild, moderate, or labile hypertension; uncooperative patients.
• Coronary insufficiency or recent myocardial infarction.
• Uremia.
• Concurrent antibiotics or sulfonamides (with ganglion blockers).
• Glaucoma; organic pyloric stenosis.

Cautions

• Orthostatic/postural hypotension and syncope.
• Paralytic ileus (may be preceded by small, frequent liquid stools).
• CNS effects: convulsions, tremor, choreiform movements, mental aberrations, paresthesias.

Adverse reactions

• ileus/constipation
• nausea, vomiting, anorexia
• orthostatic dizziness/syncope, postural hypotension
• dry mouth, glossitis
• urinary retention, impotence, decreased libido
• blurred vision, dilated pupils
• weakness, fatigue, sedation

Pregnancy Pregnancy Category C; use only if clearly needed.

Lactation Undefined