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Magnesium oxide

MAG-OX

Pronunciation: mag-NEE-zee-um OX-ide

Magnesium oxide ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Magnesium oxide ballicule

What it isMagnesium salt acting as an osmotic laxative and repletion agent; constipation and hypomagnesemia.

Why this oneHigh elemental magnesium but poor absorption makes it more reliable as a laxative than as repletion.

What limits itDiarrhea is dose-limiting, and magnesium can accumulate dangerously when kidney function is impaired.

FDA label

FDA dosingPopulationStartTargetMax
AntacidAdults1–2 tablets QD1–2 tablets QD2 tablets/day unless directed by a physician

Renal Undefined

Hepatic Undefined

Label does not state tablet strength (mg).

Available strengths

Pregnancy Undefined

Lactation Undefined

Cost

Magnesium oxide (MAG-OX)
What pharmacies pay · NADAC 9/30/26 · OTC
Strength#/mogeneric $/moCostPlus
253 mgtab30 qd$1.15not offered
400 mgtab30 qd$1.04not offered
420 mgtab30 qdnot offered
440 mgtab30 qdnot offered
241.3 mg/1000 mgtab30 qdnot offered

Other forms: Magnesium (Mg2+)

NO BOXED WARNINGS

Principal riskDiarrhea; accumulation in renal impairment

Classes and tags

Clinical profile

Therapeutic safety burden1 / 4
Overdose danger1 / 4
Weight-gain liability0 / 4
Sedation liability0 / 4
QT / Torsades0 / 4
Direct muscarinic antagonism0 / 4
Embryofetal risk1 / 4

Defining liabilityDiarrhea; hypermagnesemia with impaired clearance or bowel dysfunction

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