Morphine-6-glucuronide
from morphine
What it isMorphine-6-glucuronide, the active analgesic metabolite of morphine.
Why it mattersIt is more potent at the mu receptor than morphine itself and contributes meaningfully to analgesia during chronic dosing.
What it changesIt accumulates in renal failure, where delayed sedation and respiratory depression from M6G can outlast the parent drug.
NO BOXED WARNINGS