Lysergic acid diethylamide
LSD
What it isSerotonergic psychedelic and potent 5-HT2A agonist; investigational for anxiety.
Why this oneA single supervised dose has produced sustained anxiolytic effect in trials, which chronic dosing does not require.
What limits itTwelve-hour duration demands prolonged supervision. Not approved; contraindicated in psychosis risk.
FDA-approved for
- anxiety/depression (investigational; not approved)
Off-label
- generalized anxiety disorder (phase 3; breakthrough designation)
NO BOXED WARNINGS
Principal riskTwelve-hour duration demands prolonged supervision
Classes and tags
Clinical profile
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