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Loratadine

CLARITIN

Pronunciation: lor-AT-a-deen

Loratadine ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Loratadine ballicule
Loratadine CLARITIN mascot mnemonic cartoon
Visual mnemonic: Loratadine mascot
“Low rat dines with Clarity”

What it isSecond-generation H1 antagonist; allergic rhinitis and urticaria.

Why this oneIt causes less drowsiness than cetirizine, but fexofenadine is generally the least sedating oral option.

What limits itIts low sedation comes with weaker urticaria control than cetirizine; inadequate control often prompts a switch.

Loratadine molecular structure (skeletal formula)
Molecular structure: Loratadine

FDA-approved for

FDA label

FDA dosingPopulationStartTargetMax
Allergy relief (OTC antihistamine)Adults & children ≥6 yr10 mg (1 tablet) QD1 tablet/24 hr

Renal Undefined

Hepatic Undefined

Instructions

Available strengths

Pregnancy Undefined

Lactation Undefined

Cost

Loratadine (CLARITIN)
What pharmacies pay · NADAC 9/30/26 · OTC
Strength#/mogeneric $CostPlus
10 mgtab30 qd$1.59/mooffered
10 mgcap30 qdnot offered
5 mgchew tab30 qd$15.64/monot offered
10 mgchew tab30 qdnot offered
1 mg/mLsolper unitnot offered

NO BOXED WARNINGS

Principal riskWeaker than cetirizine in urticaria

Classes and tags

Clinical profile

Therapeutic safety burden1 / 4
Overdose danger1 / 4
Weight-gain liability1 / 4
Sedation liability1 / 4
QT / Torsades0 / 4
Direct muscarinic antagonism0 / 4
Embryofetal risk1 / 4

Defining liabilityOccasional drowsiness despite low CNS penetration

Open Loratadine in the interactive console ↗