Leptin
endogenous
What it isAdipocyte hormone signaling energy sufficiency.
Why this oneIts discovery predicted an obesity cure; instead common obesity turned out to be leptin-RESISTANT.
What limits itThat failure is why leptin replacement works only in true congenital deficiency and lipodystrophy.
NO BOXED WARNINGS
Principal riskCommon obesity is leptin-resistant, so replacement does nothing