Zolpidem SL middle-of-night

INTERMEZZO

Open Zolpidem SL middle-of-night in the interactive console ↗

Pronunciation: ZOL-pi-dem (in-ter-MET-zoe)

Zolpidem SL middle-of-night ballicule: receptor binding, kinetics and half-life diagram — Mechanism of action: Zolpidem SL middle-of-night ballicule

Zolpidem SL middle-of-night mascot mnemonic cartoon — Visual mnemonic: Zolpidem SL middle-of-night mascot
**“Intermediate Z’s”**

What it isSublingual GABA-A positive allosteric modulator in 1.75/3.5 mg strengths; insomnia marked by middle-of-the-night awakening.

Why this oneIt is the only insomnia label for middle-of-the-night awakening, targeting a single late-night awakening rather than bedtime sleep initiation.

What limits itTake only with ≥4 h of bed time remaining; women dose 1.75 mg (slower zolpidem clearance). Next-morning impairment and complex sleep behaviors can cause serious injury.

Zolpidem SL middle-of-night molecular structure (skeletal formula) — Molecular structure: Zolpidem SL middle-of-night

FDA-approved for

insomnia — middle-of-the-night awakening (2011)

Available strengths

SL tab 1.75, 3.5 mg

⚠ BOXED WARNING

Complex sleep behaviors including sleepwalking and sleep-driving

Classes and tags

Clinical profile

Therapeutic safety burden2 / 4

Overdose danger2 / 4

Weight-gain liability0 / 4

Sedation liability3 / 4

QT / Torsades0 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk2 / 4

Legacy pregnancy categoryC

Defining liabilityComplex sleep behaviors, next-day impairment, falls and additive CNS depression.

Open Zolpidem SL middle-of-night in the interactive console ↗

Memory aids: interaction avatars

CYP3A4 substrate

Open Zolpidem SL middle-of-night in the interactive console ↗