DYAZIDE
Combination product
Pronunciation: hye-droe-klor-oe-THYE-a-zide and trye-AM-ter-een
Combination of Hydrochlorothiazide and Triamterene.
Each component keeps its own pharmacology page; the combination itself adds no new mechanism.
Components (2)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Hypertension or edema (in patients who develop hypokalemia on hydrochlorothiazide alone or in whom hypokalemia cannot be risked) | Adults | 37.5/25 mg: 1 tablet QD (or initiate here if hypokalemia cannot be risked) | 37.5/25 mg one to two QD, or 75/50 mg one QD | Two 37.5/25 mg tablets daily, or one 75/50 mg tablet daily |
Renal Contraindicated in anuria and acute/chronic renal insufficiency or significant renal impairment; mild impairment requires frequent electrolyte monitoring
Hepatic Use with caution in impaired hepatic function or progressive liver disease (may precipitate hepatic coma)
Avoid in diabetic patients; monitor electrolytes
Instructions
- Give as a single daily dose with monitoring of serum potassium
- Avoid divided dosing (increased risk of electrolyte imbalance and renal dysfunction)
- Not indicated for initial therapy of edema or hypertension
Available strengths
- tab 25/37.5, 50/75 mg
- cap 25/37.5 mg
Contraindications
- Hyperkalemia — elevated serum potassium levels (greater than or equal to 5.5 mEq/liter)
- Concomitant use of other potassium-conserving agents (e.g., spironolactone, amiloride, other triamterene-containing products) or potassium supplementation/potassium-containing salt substitutes/potassium-enriched diets
- Anuria, acute and chronic renal insufficiency, or significant renal impairment
Cautions
- Hyperkalemia (may be fatal)
- Metabolic or respiratory acidosis
- Acute myopia and secondary angle-closure glaucoma
- Electrolyte imbalance and BUN increases
- Hepatic coma risk in liver disease
- Renal stones
- Folic acid deficiency
- Hyperuricemia/gout
- Non-melanoma skin cancer (hydrochlorothiazide)
Adverse reactions
- Jaundice
- Nausea/vomiting
- Diarrhea
- Dizziness
- Headache
- Orthostatic hypotension
- Hyperkalemia/hypokalemia
- Hyponatremia
- Elevated BUN/creatinine
- Photosensitivity
- Rash
Pregnancy Safe use in pregnancy not established; use only if potential benefit justifies risk to fetus (thiazides/triamterene cross placenta)
Lactation Thiazides excreted in human breast milk; triamterene appears in animal milk; if drug essential, stop nursing
Cost
Part D rank #163.