Hexamethonium
C6
What it isGanglionic nicotinic blocker; historical antihypertensive.
Why this oneIt demonstrated that blood pressure could be lowered pharmacologically at all.
What limits itBlocking both autonomic limbs caused intolerable effects. Of historical interest only.
NO BOXED WARNINGS
Principal riskBlocking both autonomic limbs caused intolerable effects
Classes and tags
Clinical profile
Defining liabilityProfound autonomic blockade and potentially serious pulmonary toxicity