Glycine

FDA label

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Renal Undefined

Hepatic Undefined

Container height above ~60 cm (2 ft) increases intravascular absorption of the irrigating fluid.

Instructions

• Administer only by transurethral instillation with appropriate urologic instrumentation.
• Use a disposable irrigation set.
• Not for injection by usual parenteral routes.
• Keep container height no more than ~60 cm (2 ft) above the operating table — greater height increases intravascular absorption of irrigant.
• Inspect visually for particulate matter and discoloration before use whenever the container permits.
• Additives may be incompatible — consult a pharmacist, use aseptic technique, mix thoroughly, and do not store.

Available strengths

• irrigant 1.5 g/100 mL
• sol 1.5 g/100 mL

Contraindications

• Anuria
• Not for injection by usual parenteral routes

Cautions

• Intravascular absorption of irrigant can cause fluid and electrolyte disturbance — hyponatremia (TUR syndrome), fluid overload, marked diuresis, edema, acidosis.
• Hyperammonemia with resulting coma and/or encephalopathy can follow glycine absorption.
• Cardiovascular and pulmonary consequences of absorption: hypotension, tachycardia, angina-like pain, pulmonary congestion.
• Discontinue the irrigant if any adverse reaction occurs, evaluate the patient, and save the remaining fluid for examination if needed.

Adverse reactions

• From intravascular absorption: salivation, nausea, lightheadedness.
• Fluid/electrolyte: acidosis, electrolyte loss, marked diuresis, urinary retention, edema, dry mouth, thirst, dehydration.
• Hyponatremia progressing to coma; secondary hyponatremia from fluid overload; hyperammonemia with coma/encephalopathy.
• Cardiovascular: hypotension, tachycardia, angina-like pain. Pulmonary: pulmonary congestion.
• Other: blurred vision, transient blindness, convulsions, vomiting, rhinitis, chills, vertigo, backache, urticaria. Allergic reactions to glycine are unknown or exceedingly rare.

Pregnancy Pregnancy Category C — animal reproduction studies not conducted; unknown whether it can cause fetal harm. Give to a pregnant woman only if clearly needed.

Lactation Undefined