Withdrawn from the market (safety)
Glutethimide
DORIDEN
What it isPiperidinedione sedative-hypnotic; withdrawn.
Why this oneIt was promoted as a safer barbiturate alternative.
What limits itIt was not — overdose was notoriously difficult to manage, with cyclical coma. US approval withdrawn in 1993.
FDA-approved for
- insomnia (US approval withdrawn 1993)
NO BOXED WARNINGS
Principal riskWithdrawn; a difficult and cyclical overdose
Classes and tags
Clinical profile
Defining liabilityDependence and prolonged overdose coma