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Gemigliptin

ZEMIGLO

Gemigliptin ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Gemigliptin ballicule

What it isOral DPP-4 inhibitor that raises incretin (GLP-1/GIP) levels to enhance glucose-dependent insulin secretion.

Why this oneA weight-neutral, low-hypoglycemia oral option for type 2 diabetes, approved in South Korea (Zemiglo) rather than the US.

What limits itLike other gliptins it carries a risk of pancreatitis and arthralgia, and being non-FDA-approved it has limited US prescribing and interaction data.

Gemigliptin molecular structure (skeletal formula)
Molecular structure: Gemigliptin

NO BOXED WARNINGS

Principal riskNo FDA boxed warning.

Classes and tags

Clinical profile

Therapeutic safety burden1 / 4
Overdose danger1 / 4
Weight-gain liability1 / 4
Sedation liability0 / 4
QT / Torsades0 / 4
Direct muscarinic antagonism0 / 4
Embryofetal risk2 / 4

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