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Flupentixol

DEPIXOL

Flupentixol ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Flupentixol ballicule

What it isThioxanthene antipsychotic; schizophrenia, and at low dose depression outside the US.

Why this oneA long-acting depot at low cost, with an antidepressant indication the US class does not carry.

What limits itExtrapyramidal effects and tardive dyskinesia. Not US-approved.

Flupentixol molecular structure (skeletal formula)
Molecular structure: Flupentixol

FDA-approved for

Off-label

NO BOXED WARNINGS

Principal riskExtrapyramidal effects and tardive dyskinesia

Classes and tags

Clinical profile

Therapeutic safety burden2 / 4
Overdose danger3 / 4
Weight-gain liability1 / 4
Sedation liability2 / 4
QT / Torsades1 / 4
Direct muscarinic antagonism0 / 4
Embryofetal risk2 / 4

Defining liabilityExtrapyramidal symptoms, hyperprolactinemia and tardive dyskinesia

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