Not available in the U.S.
Mechanism of action: Flupentixol ballicule
What it isThioxanthene antipsychotic; schizophrenia, and at low dose depression outside the US.
Why this oneA long-acting depot at low cost, with an antidepressant indication the US class does not carry.
What limits itExtrapyramidal effects and tardive dyskinesia. Not US-approved.
Molecular structure: Flupentixol
FDA-approved for
- schizophrenia / depression (non-US)
Off-label
- schizophrenia
- depression at low dose (approved in Europe and Canada)
Principal riskExtrapyramidal effects and tardive dyskinesia
Classes and tags
Clinical profile
Therapeutic safety burden2 / 4
Overdose danger3 / 4
Weight-gain liability1 / 4
Sedation liability2 / 4
QT / Torsades1 / 4
Direct muscarinic antagonism0 / 4
Embryofetal risk2 / 4
Defining liabilityExtrapyramidal symptoms, hyperprolactinemia and tardive dyskinesia
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