5-HMT
from fesoterodine
What it is5-hydroxymethyl tolterodine, the active metabolite of both fesoterodine and tolterodine; overactive bladder.
Why it mattersTwo marketed drugs converge on this one molecule, which is why they behave alike.
What it changesAnticholinergic burden. Fesoterodine reaches it by esterase hydrolysis, bypassing CYP2D6 variability; tolterodine does not.
NO BOXED WARNINGS
Principal riskAnticholinergic burden