Fexofenadine

ALLEGRA

Pronunciation: fex-oe-FEN-a-deen (a-LE-gra)

What it isSecond-generation H1 antagonist and P-gp substrate; allergic rhinitis and urticaria.

Why this oneIt is actively excluded from the CNS by P-gp, making it the least sedating antihistamine.

What limits itFruit juice reduces absorption substantially through OATP inhibition. Cations block it; renally adjusted.

FDA-approved for

FDA dosing	Population	Start	Target	Max
Allergy relief	≥12 yr	18 mg QD		1 tablet/24h

Renal Undefined

Hepatic Undefined

Available strengths

Pregnancy Undefined

Lactation Undefined

Fexofenadine (ALLEGRA)

What pharmacies pay · NADAC 9/30/26 · OTC

Strength		#/mo	generic $/mo	CostPlus
60 mg	tab	30 qd	$4.59	offered
180 mg	tab	30 qd	$6.91	offered

NO BOXED WARNINGS

Principal riskFruit juice substantially reduces absorption

Therapeutic safety burden1 / 4

Overdose danger1 / 4

Weight-gain liability0 / 4

Sedation liability0 / 4

QT / Torsades0 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk1 / 4

Legacy pregnancy categoryC

Defining liabilityReduced absorption with fruit juice; renal dosing considerations