Withdrawn from the market (safety)
Ezogabine
POTIGA
Pronunciation: e-ZOG-a-been (poe-TEE-ga)
What it isKCNQ potassium channel opener; focal seizures. Withdrawn.
Why this oneA mechanism no other antiepileptic used — opening a potassium channel rather than blocking sodium.
What limits itBlue-gray skin and retinal pigment changes ended its marketing.
FDA-approved for
- partial-onset seizures (2011)
⚠ BOXED WARNING
- Retinal abnormalities and potential vision loss
Classes and tags
Clinical profile
Legacy pregnancy categoryC
Defining liabilityRetinal pigmentation/vision risk, urinary retention and CNS impairment