D-Serine
NMDA co-agonist
What it isD-serine, the principal endogenous co-agonist at the NMDA glycine site.
Why this oneThe channel cannot open without it, which is why glycine-site drugs and D-amino acid oxidase inhibitors are pursued in schizophrenia.
What limits itNephrotoxicity at high doses in animals has limited direct supplementation.
NO BOXED WARNINGS
Principal riskNephrotoxicity at high doses in animals