COSOPT
Combination product
Pronunciation: dor-ZOEL-a-mide and TYE-moe-loel (KOE-sopt)
Combination of Dorzolamide and Timolol.
Each component keeps its own pharmacology page; the combination itself adds no new mechanism.
Components (2)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Elevated IOP in open-angle glaucoma or ocular hypertension (insufficiently responsive to beta-blockers) | Adults | 1 drop in affected eye(s) BID | 1 drop BID | 1 drop BID |
Renal Not recommended if CrCl <30 mL/min (not studied in severe renal impairment)
Hepatic Use with caution (not studied in hepatic impairment)
Instructions
- 1 drop in affected eye(s) twice daily
- If using more than one topical ophthalmic drug, administer at least 5 minutes apart
Available strengths
- drops 2/0.5 %
- sol 20/5 mg/mL
Contraindications
- Bronchial asthma or history of bronchial asthma; severe COPD
- Sinus bradycardia, second- or third-degree AV block, overt cardiac failure, cardiogenic shock
Cautions
- Systemic beta-blockade effects (severe respiratory reactions incl. bronchospasm; cardiac failure)
- Sulfonamide hypersensitivity (severe reactions incl. SJS/TEN, blood dyscrasias)
- May mask hypoglycemia and thyrotoxicosis
- Potentiation of muscle weakness (myasthenia gravis)
- Corneal edema risk with low endothelial cell counts; bacterial keratitis with contaminated containers
Adverse reactions
- Taste perversion
- Ocular burning/stinging
- Conjunctival hyperemia
- Blurred vision
- Superficial punctate keratitis
- Eye itching
Pregnancy Use only if potential benefit justifies potential risk to fetus (no adequate well-controlled studies)
Lactation Timolol detected in human milk; decide whether to discontinue nursing or drug
Cost
COSOPT
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 2/0.5 % | drops | per unit | not offered |
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. COSOPT is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.
Part D rank #171.