Not available in the U.S.
Domperidone
MOTILIUM
What it isPeripheral D2 antagonist; gastroparesis and nausea outside the US.
Why this oneIt is prokinetic and antiemetic without crossing the blood-brain barrier, so no extrapyramidal effects.
What limits itQT prolongation and sudden death kept it off the US market. It raises prolactin.
FDA-approved for
- gastroparesis / antiemetic (non-US)
Off-label
- gastroparesis
- nausea and vomiting
- lactation induction (approved outside the US)
⚠ BOXED WARNING
- QT prolongation and sudden cardiac death
Classes and tags
Clinical profile
Defining liabilityQT-related arrhythmia and hyperprolactinemia