N,N-dimethyltryptamine
DMT
What it isShort-acting serotonergic psychedelic and 5-HT2A agonist; the active principle of ayahuasca.
Why this oneIts brevity when smoked, and its oral activity only with an MAOI, define how it is used.
What limits itOral use requires MAO inhibition, which brings tyramine and serotonergic interaction risk. Investigational; not approved.
FDA-approved for
- depression (investigational; not approved)
Off-label
- depression (early-phase trials)
NO BOXED WARNINGS
Principal riskOral use requires MAO inhibition, which brings tyramine and serotonergic interaction risk
Classes and tags
Clinical profile
Defining liabilityIntense perceptual changes, anxiety and transient cardiovascular activation