DHEAS
neurosteroid
What it isThe sulfated, circulating storage form of DHEA and a GABA-A negative modulator.
Why this oneIts long half-life makes it the measured marker of adrenal androgen production.
What limits itIts GABA-A antagonism opposes allopregnanolone, so the two neurosteroids pull in opposite directions.
NO BOXED WARNINGS
Principal riskEndogenous or dietary; no boxed warning applies
Classes and tags
Clinical profile
Defining liabilityFetal bradycardia/asphyxia and anaphylaxis during historical cervical-ripening treatment