Curcumin
turmeric
“Curry-Comin'-to-'Merica”
What it isThe principal curcuminoid of turmeric, inhibiting NF-kB and several inflammatory pathways.
Why this oneIt is the most studied dietary anti-inflammatory, with modest trial evidence in osteoarthritis.
What limits it⚑ Oral bioavailability is very low, which is why products add piperine — and piperine itself inhibits CYP3A4 and P-gp. Curcumin inhibits CYP3A4, CYP2C9 and UGT, and can raise warfarin effect.
Available strengths
- cap 500 mg (95% curcuminoids)
NO BOXED WARNINGS
Principal riskIt inhibits CYP3A4, CYP2C9 and UGT, and can raise warfarin effect