Creatinine
endogenous
“Kreat in 9”
Greek kreat = flesh
What it isEndogenous muscle metabolite filtered by the glomerulus and secreted by tubules.
Why it mattersIt is the marker every renal dose adjustment rests on, which is why drugs that block its tubular SECRETION matter.
What it changesTrimethoprim, cimetidine, dolutegravir, bictegravir and cobicistat raise it without changing GFR — a rise on these is not injury.
NO BOXED WARNINGS
Principal riskSeveral drugs raise it by blocking secretion, not by injury
Classes and tags
Clinical profile
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