Clotrimazole
LOTRIMIN
Pronunciation: kloe-TRIM-a-zoel
“Chloe, trim a sole”
What it isImidazole CYP51 inhibitor; tinea and cutaneous, vulvovaginal or oropharyngeal candidiasis.
Why this oneIt spans OTC skin and vaginal products plus prescription oral troches, an unusually broad set of local formulations.
What limits itTroches can raise tacrolimus exposure despite minimal absorption; local burning occurs, and no form treats invasive disease.
FDA-approved for
- dermatophyte and candidal infections
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Athlete's foot / ringworm | Adult (supervise children) | Apply thin layer BID (AM & PM) | Apply thin layer BID x4 weeks | |
| Jock itch | Adult (supervise children) | Apply thin layer BID (AM & PM) | Apply thin layer BID x2 weeks |
Renal Undefined
Hepatic Undefined
Athlete's foot/ringworm: 4-week course; jock itch: 2-week course
Instructions
- Wash and dry the affected area thoroughly before applying
- Athlete's foot/ringworm: use daily for 4 weeks; jock itch: use daily for 2 weeks
- Not effective on the scalp or nails
- Supervise children's use; if condition persists longer than the course, ask a doctor
Available strengths
- sol 1 %
- cream 1, 2 %
- granules 100 kg/100 kg
- lozenge 10 mg
- drops 1 %
- gel 0.01 kg/kg
- gel 10 mg/g
- ointment 1 g/100 g
- + 10 other marketed forms not shown
Cautions
- Discontinue and consult a doctor if the condition persists beyond the treatment course
Pregnancy Undefined
Lactation Undefined
Cost
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 1 % | sol | per unit | not offered | |
| 1 % | cream | per unit | not offered | |
| 2 % | cream | per unit | not offered |
Generic entry1993
NO BOXED WARNINGS
Principal riskLittle; topical
Classes and tags
Clinical profile
Legacy pregnancy categoryC
Defining liabilityLocal irritation or hypersensitivity; systemic toxicity is minimal with correct local use.